Alpha-lipoic acid is a naturally occurring compound made in the body that is involved in energy metabolism. It functions as a powerful antioxidant, helping protect cells from oxidative stress and supporting overall metabolic health. Unlike many antioxidants, ALA is both water- and fat-soluble, allowing it to work in every part of the body—including the brain, liver, and nervous system.
ALA exists in two enantiomeric forms:
- R-ALA (R(+)-alpha-lipoic acid) – The biologically active isomer, synthesized naturally in the body.
- S-ALA—A synthetic form with lower bioactivity. Most supplements contain a racemic mixture (R/S).
Common Forms in the Market
- Capsules/Tablets (Standard or Sustained Release)
- Liposomal Liquid (For Liquid dosage)
- Powders (for blending into shakes or formulas)
✅ Key Benefits
- Antioxidant Protection
Neutralizes harmful free radicals, slowing down cellular aging and protecting tissues.
- Diabetes Support
Improves insulin sensitivity and helps manage blood sugar levels. Clinically used in diabetic neuropathy treatment (especially in Europe).
- Nerve Health
Reduces symptoms like tingling, numbness, and pain associated with nerve damage.
- Liver Support
Promotes detoxification and helps protect the liver from damage due to alcohol, medications, or toxins.
- Brain and Cognitive Function
Crosses the blood-brain barrier, supports brain health, and may slow progression of neurodegenerative diseases.
- Skin and Anti-Aging
Helps reduce fine lines, boosts collagen, and protects skin from environmental stress.
| Form | Typical Strength | Description |
| Alpha Lipoic Acid (Racemic) | 98% | Most common, includes R and S isomers |
| R-Alpha Lipoic Acid (Natural Isomer) | 95%–99% | More bioavailable and active form |
| ALA Granular or DC Grade | 95%–98% | Direct compression grade for tablets |
| ALA Coated/Encapsulated | Variable (usually 50–70%) | To improve stability and taste |